complete mitochondrial genome sequence of three tetrahymena species reveals mutation hot spots and accelerated nonsynonymous substitutions in ymf genes完整的线粒体基因组序列的三个四膜虫物种显示突变热点和加速产生替换ymf基因.pdfVIP

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complete mitochondrial genome sequence of three tetrahymena species reveals mutation hot spots and accelerated nonsynonymous substitutions in ymf genes完整的线粒体基因组序列的三个四膜虫物种显示突变热点和加速产生替换ymf基因.pdf

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complete mitochondrial genome sequence of three tetrahymena species reveals mutation hot spots and accelerated nonsynonymous substitutions in ymf genes完整的线粒体基因组序列的三个四膜虫物种显示突变热点和加速产生替换ymf基因

Complete Mitochondrial Genome Sequence of Three Tetrahymena Species Reveals Mutation Hot Spots and Accelerated Nonsynonymous Substitutions in Ymf Genes Mike M. Moradian*, Denis Beglaryan, Jill M. Skozylas, Varand Kerikorian Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, California, United States of America The ciliate Tetrahymena, a model organism, contains divergent mitochondrial (Mt) genome with unusual properties, where half of its 44 genes still remain without a definitive function. These genes could be categorized into two major groups of KPC (known protein coding) and Ymf (genes without an identified function). To gain insights into the mechanisms underlying gene divergence and molecular evolution of Tetrahymena (T.) Mt genomes, we sequenced three Mt genomes of T.paravorax, T.pigmentosa, and T.malaccensis . These genomes were aligned and the analyses were carried out using several programs that calculate distance, nucleotide substitution (dn/ds), and their rate ratios (v) on individual codon sites and via a sliding window approach. Comparative genomic analysis indicated a conserved putative transcription control sequence, a GC box, in a region where presumably transcription and replication initiate. We also found distinct features in Mt genome of T.paravorax despite similar genome organization among these ,47 kb long linear genomes. Another significant finding was the presence of at least one or more highly variable regions in Ymf genes where majority of substitutions were concentrated. These regions were mutation hotspots where elevated distances and the dn/ds ratios were primarily due to an increase in the number of nonsynonymous substitutions, suggesting relaxed selective constraint. However, in a few Ymf genes, accelerated rates of nonsynonymous substitutions may be due to