有哪些信誉好的足球投注网站convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response收敛的老鼠和人类研究的证据表明,锌指蛋白326基因参与抗抑郁药物治疗的反应.pdfVIP
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convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response收敛的老鼠和人类研究的证据表明,锌指蛋白326基因参与抗抑郁药物治疗的反应
Convergent Evidence from Mouse and Human Studies Suggests the Involvement of Zinc Finger Protein 326 Gene in Antidepressant Treatment Response 1,2 5,6 4 7 8 8 Ying-Jay Liou , Chien-Hsiun Chen , Chih-Ya Cheng , Shiow-Yi Chen , Tai-Jui Chen , Younger W-Y Yu , Fang-Shin Nian3, Shih-Jen Tsai1,2, Chen-Jee Hong1,2,3* 1 Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, 2 Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 3 Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, 4 Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 5 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, 6 Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, 7 Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan, 8 Yu’s Psychiatric Clinic, Kaohsiung, Taiwan Abstract Objectives: The forced swim test (FST) is a commonly used model to predict antidepressant efficacy. Uncovering the genetic basis of the model may unravel the mechanism of antidepressant treatment. Methods: FVB/NJ (FVB) and C57BL/6J (B6) were first identified as the response and non-response strains to fluoxetine (a serotonin-specific reuptake inhibitor antidepressant) treatment in the mouse FST. Simple-interval (SIM) and composite- interval (CIM) mappings were applied to map the quantitative trait loci (QTLs) of the anti-immobility effect of fluoxetine in FST (FSTFLX) in 865 male B6 6FVB-F2 mice. The brain mRNA expressions of the gene with the maximum QTL-linkage signal for FSTFLX after the FST were compared between B6 and F
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