有哪些信誉好的足球投注网站control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins通过微分控制线粒体形态的线粒体融合与分裂的蛋白质的相互作用.pdfVIP
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control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins通过微分控制线粒体形态的线粒体融合与分裂的蛋白质的相互作用
Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins Pinwei Huang, Chad A. Galloway, Yisang Yoon* Mitochondrial Research and Innovation Group, Department of Anesthesiology, Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America Abstract Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change. Perturbation of the fission/fusion balance is associated with many disease conditions. However, underlying mechanisms of the fission/fusion balance are not well understood. Mitochondrial fission in mammals requires the dynamin-like protein DLP1/Drp1 that is recruited to the mitochondrial surface, possibly through the membrane-anchored protein Fis1 or Mff. Additional dynamin-related GTPases, mitofusin (Mfn) and OPA1, are associated with the outer and inner mitochondrial membranes, respectively, and mediate fusion of the respective membranes. In this study, we found that two heptad-repeat regions (HR1 and HR2) of Mfn2 interact with each other, and that Mfn2 also interacts with the fission protein DLP1. The association of the two heptad-repeats of Mfn2 is fusion inhibitory whereas a positive role of the Mfn2/DLP1 interaction in mitochondrial fusion is suggested. Our results imply that the differential binding of Mfn2-HR1 to HR2 and DLP1 regulates mitochondrial fusion and that DLP1 may act as a regulatory factor for efficient execution of both fusion and fission of mitochondria. Citation: Huang P, Galloway CA, Yoon Y (2011) Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins. PLoS O
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