common variants of tlr1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis常见的变体tlr1与器官功能障碍在脓毒症和持续的炎性反应.pdfVIP

Common Variants of TLR1 Associate with Organ Dysfunction and Sustained Pro-Inflammatory Responses during Sepsis 1,2 1,2 1,3 ´ 1,4 1,4 Maria Pino-Yanes , Almudena Corrales , Milena Casula , Jesus Blanco , Arturo Muriel , Elena 5 ´ 3 1,6,7 1,6,7 1,8 ´ Espinosa , Miguel Garcıa-Bello , Antoni Torres , Miguel Ferrer , Elizabeth Zavala , Jesus Villar1,3,9*., Carlos Flores 1,2*., for the GRECIA and GEN-SEP groups 1 CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, 2 Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain, 3 Research Unit, Multidisciplinary Organ Dysfunction Evaluation Research Network, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain, 4 Intensive Care Unit, ´ Hospital Universitario Rıo Hortega, Valladolid, Spain, 5 Department of Anaesthesia, Hospital Universitario N.S. de Candelaria, Tenerife, Spain, 6 Pneumology Department, ` Clinic Institute of Thorax, Hospital Clinic, Barcelona, Spain, 7 Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain, 8 Surgical Intensive Care Unit, Department of Anesthesia, Hospital Clinic, Barcelona, Spain, 9 Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada Abstract Background: Toll-like receptors (TLRs) are critical components for host pathogen