computational identification and modeling of crosstalk between phosphorylation, o-β-glycosylation and methylation of foxo3 and implications for cancer therapeutics计算识别和建模磷酸化之间的串扰,o-β-glycosylation foxo3的甲基化和对癌症治疗的影响.pdfVIP

下载本文档

0
0
约8.07万字
约 21页
2017-09-12 发布于上海
举报
版权申诉

computational identification and modeling of crosstalk between phosphorylation, o-β-glycosylation and methylation of foxo3 and implications for cancer therapeutics计算识别和建模磷酸化之间的串扰,o-β-glycosylation foxo3的甲基化和对癌症治疗的影响.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

computational identification and modeling of crosstalk between phosphorylation, o-β-glycosylation and methylation of foxo3 and implications for cancer therapeutics计算识别和建模磷酸化之间的串扰,o-β-glycosylation foxo3的甲基化和对癌症治疗的影响

Int. J. Mol. Sci. 2012, 13, 2918-2938; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Computational Identification and Modeling of Crosstalk between Phosphorylation, O-β-glycosylation and Methylation of FoxO3 and Implications for Cancer Therapeutics Azeem Mehmood Butt 1,2,†, Dandan Feng 2,†, Muhammad Idrees 1, Yigang Tong 3 and Jun Lu 2,* 1 Division of Molecular Virology, National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore 53700, Pakistan; E-Mails: azeem@.pk (A.M.B.); idreeskhan@.pk (M.I.) 2 Cancer Biotherapy Ward, Beijing YouAn Hospital, Capital Medical University, FengTai District, Beijing 100069, China; E-Mail: fengdandan83@ 3 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China; E-Mail: tong62035@ † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: lujun98@; Tel./Fax: +86-10-6329-1028. Received: 30 January 2012; in revised form: 23 February 2012 / Accepted: 28 February 2012 / Published: 5 March 2012 Abstract: FoxO3 is a member of the forkhead class of transcription factors and plays a major role in the regulation of diverse cellular processes, including cell cycle arrest, DNA repair, and protection from stress stimuli by detoxification of reactive oxygen species. In addition, FoxO3 is a