有哪些信誉好的足球投注网站comprehensive gene-expression survey identifies wif1 as a modulator of cardiomyocyte differentiation基因表达综合调查识别wif1调制器的心肌细胞分化.pdfVIP
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comprehensive gene-expression survey identifies wif1 as a modulator of cardiomyocyte differentiation基因表达综合调查识别wif1调制器的心肌细胞分化
Comprehensive Gene-Expression Survey Identifies Wif1 as a Modulator of Cardiomyocyte Differentiation 1 2 1 1 1 Henk P. J. Buermans *, Bram van Wijk , Margriet A. Hulsker , Niels C. H. Smit , Johan T. den Dunnen , 1 2 2 1 Gertjan B. van Ommen , Antoon F. Moorman , Maurice J. van den Hoff , Peter A. C. ’t Hoen 1 Human and Clinical Genetics/Leiden University Medical Center, Leiden, The Netherlands, 2 Heart Failure Research Center/Academic Medical Center, Amsterdam, The Netherlands Abstract During chicken cardiac development the proepicardium (PE) forms the epicardium (Epi), which contributes to several non- myocardial lineages within the heart. In contrast to Epi-explant cultures, PE explants can differentiate into a cardiomyocyte phenotype. By temporal microarray expression profiles of PE-explant cultures and maturing Epi cells, we identified genes specifically associated with differentiation towards either of these lineages and genes that are associated with the Epi- lineage restriction. We found a central role for Wnt signaling in the determination of the different cell lineages. Immunofluorescent staining after recombinant-protein incubation in PE-explant cultures indicated that the early upregulated Wnt inhibitory factor-1 (Wif1), stimulates cardiomyocyte differentiation in a similar manner as Wnt stimulation. Concordingly, in the mouse pluripotent embryogenic carcinoma cell line p19cl6, early and late Wif1 exposure enhances and attenuates differentiation, respectively. In ovo exposure of the HH12 chicken embry
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