commitment to the regulatory t cell lineage requires carma1 in the thymus but not in the periphery承诺的调节性t细胞谱系需要carma1胸腺但不是在外围.pdfVIP

PLoS BIOLOGY Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery 1* 1 2 1 3 Michael J. Barnes , Philippe Krebs , Nathaniel Harris , Celine Eidenschenk , Rosana Gonzalez-Quintial , 1 1 1 1 3 1 Carrie N. Arnold , Karine Crozat , Sosathya Sovath , Eva Marie Moresco , Argyrios N. Theofilopoulos , Bruce Beutler , 2* Kasper Hoebe 1 Department of Genetics, The Scripps Research Institute, La Jolla, California, United States of America, 2 Division of Molecular Immunology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America, 3 Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America Regulatory T (Treg) cells expressing forkhead box P3 (Foxp3) arise during thymic selection among thymocytes with þ T modestly self-reactive T cell receptors. In vitro studies suggest Foxp3 can also be induced among peripheral CD4 cells in a cytokine dependent manner. Treg cells of thymic or peripheral origin may serve different functions in vivo, but both populations are phenotypically indistinguishable in wild-type mice. Here we show that mice with a Carma1 point þ þ mutation lack thymic CD4 Foxp3 Treg cells and demonstr