comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis表达谱的比较在体内卵巢上皮癌和卵巢癌识别新的候选基因参与了疾病的发病机理.pdfVIP

Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis 1,2 1,2 1,2 2 Catherine Emmanuel *, Natalie Gava , Catherine Kennedy , Rosemary L. Balleine , Raghwa 3 1 1 1 4 4 Sharma , Gerard Wain , Alison Brand , Russell Hogg , Dariush Etemadmoghadam , Joshy George , 7 2 Australian Ovarian Cancer Study Group, Michael J. Birrer , Christine L. Clarke , Georgia Chenevix- Trench5, David D. L. Bowtell4,6, Paul R. Harnett1,2, Anna deFazio1,2 1 Department of Gynaecological Oncology, Westmead Hospital, Westmead, New South Wales, Australia, 2 Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales, Australia, 3 Department of Anatomical Pathology, Westmead Hospital, Westmead, New South Wales, Australia, 4 Cancer Genomics and Genetics, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia, 5 Cancer Genetics Laboratory, Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, 6 Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia, 7 Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Molecular events leading to epithelial ovarian cancer are poorly understood but ovulatory hormones and a high number of life-time ovulations with concomitant proliferation,