colocalization of 14-3-3 proteins with sod1 in lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal modelcolocalization 14-3-3蛋白在路易sod1身体,就像透明的夹杂物在家族性肌萎缩性脊髓侧索硬化症情况下和动物模型.pdfVIP

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colocalization of 14-3-3 proteins with sod1 in lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal modelcolocalization 14-3-3蛋白在路易sod1身体,就像透明的夹杂物在家族性肌萎缩性脊髓侧索硬化症情况下和动物模型.pdf

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colocalization of 14-3-3 proteins with sod1 in lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal modelcolocalization 14-3-3蛋白在路易sod1身体,就像透明的夹杂物在家族性肌萎缩性脊髓侧索硬化症情况下和动物模型

Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model 1. 1. 1 2 1,2 Yoko Okamoto , Yoshitomo Shirakashi , Masafumi Ihara *, Makoto Urushitani , Miki Oono , 1 1 3 4 5 Yasuhiro Kawamoto , Hirofumi Yamashita , Shun Shimohama , Shinsuke Kato , Asao Hirano , Hidekazu 6 1 1 Tomimoto , Hidefumi Ito , Ryosuke Takahashi 1 Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2 Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga, Japan, 3 Department of Neurology, Sapporo Medical University School of Medicine, Hokkaido, Japan, 4 Department of Neuropathology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Tottori, Japan, 5 Division of Neuropathology, Department of Pathology, Montefiore Medical Center, New York, New York, United States of America, 6 Department of Neurology, Mie University Graduate School of Medicine, Mie, Japan Abstract Background and Purpose: Cu/Zn superoxide dismutase (SOD1) is a major component of Lewy body-like hyaline inclusion (LBHI) found in the postmortem tissue of SOD1-linked familial amyotrophic lateral sclerosis (FALS) patients. In our recent studies, 14-3-3 proteins have been found in the ubiquitinated inclusions inside the anterior horn cells of spinal cords with sporadic amyotrophic lateral sclerosis (ALS). To further investigate the role of 14-3-3 proteins in ALS, we performed immunohistochemical analysis of 14