common household chemicals and the allergy risks in pre-school age children常见的家用化学品和学龄前儿童的过敏风险.pdfVIP

Common Household Chemicals and the Allergy Risks in Pre-School Age Children 1 2 3 4 1 Hyunok Choi , Norbert Schmidbauer , Jan Sundell , Mikael Hasselgren , John Spengler , Carl-Gustaf Bornehag5,6* 1 Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, 2 Norwegian Institute for Air Research, Kjeller, Norway, 3 Department of Building Science, School of Architecture, Tsinghua University, Beijing, China, 4 Primary Care Research Unit, County Council of Varmland, Karlstad, Sweden, 5 Public Health Sciences, Karlstad University, Karlstad, Sweden, 6 SP Technical Research Institute of Sweden, Boras, Sweden Abstract Background: The risk of indoor exposure to volatile organic compounds (VOCs) on allergic airway diseases in children remains unknown. Objective: We examined the residential concentrations of VOCs, emitted from building materials, paints, furniture, and other lifestyle practices and the risks of multiple allergic diseases as well as the IgE-sensitization in pre-school age children in Sweden. Methods: In a case-control investigation (198 case children with asthma and allergy and 202 healthy controls), air samples were collected in the room where the child slept. The air samples were analyzed for the levels of eight classes of VOCs. Results: A natural-log unit of summed propylene glycol and glycol ethers (PGEs) in bedroom air (equal to interquartile 3 range, or 3.43 – 15.65 mg/m ) was associated with 1.5-fold greater likelihood of being a case (95% CI, 1.1 – 2.1), 1.5-fold greater likelihood of asthma (95% CI, 1.0 – 2.3), 2.8-fold greater likelihood of rhinitis (95% CI, 1.6 – 4.7), and 1.6-fold greater