common polymorphisms in mtnr1b, g6pc2 and gck are associated with increased fasting plasma glucose and impaired beta-cell function in chinese subjects常见的多态性mtnr1b g6pc2,gck与增加中国受试者空腹血浆葡萄糖和β细胞功能受损.pdfVIP

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common polymorphisms in mtnr1b, g6pc2 and gck are associated with increased fasting plasma glucose and impaired beta-cell function in chinese subjects常见的多态性mtnr1b g6pc2,gck与增加中国受试者空腹血浆葡萄糖和β细胞功能受损.pdf

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common polymorphisms in mtnr1b, g6pc2 and gck are associated with increased fasting plasma glucose and impaired beta-cell function in chinese subjects常见的多态性mtnr1b g6pc2,gck与增加中国受试者空腹血浆葡萄糖和β细胞功能受损

Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects 1. 1. 1 1 1 Claudia Ha Ting Tam , Janice Sin Ka Ho , Ying Wang , Heung Man Lee , Vincent Kwok Lim Lam , 4 4 1 1 1,2,3 Soren Germer , Mitchell Martin , Wing Yee So , Ronald Ching Wan Ma *, Juliana Chung Ngor Chan , Maggie Chor Yin Ng1¤ 1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People’s Republic of China, 2 Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People’s Republic of China, 3 Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People’s Republic of China, 4 Roche Pharmaceuticals, Nutley, New Jersey, United States of America Abstract Background: Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2), glucokinase (GCK) and glucokinase regulatory protein (GCKR) as candidate genes for type 2 diabetes (T2D) acting through elevated fasting plasma glucose (FPG). We examined the associations of the reported common variants of these genes with T2D and glucose homeostasis in three independent Chinese cohorts. Methodology/Principal