有哪些信誉好的足球投注网站cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice认知和socio-emotional赤字血小板源生长因子receptor-β基因敲除小鼠.pdfVIP
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cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice认知和socio-emotional赤字血小板源生长因子receptor-β基因敲除小鼠
Cognitive and Socio-Emotional Deficits in Platelet- Derived Growth Factor Receptor-b Gene Knockout Mice 1 1 1 2 3 Phuong Thi Hong Nguyen , Tomoya Nakamura , Etsuro Hori , Susumu Urakawa , Teruko Uwano , 1 1 1 4 4 4 Juanjuan Zhao , Ruixi Li , Nguyen Duy Bac , Takeru Hamashima , Yoko Ishii , Takako Matsushima , 2 4 1 Taketoshi Ono , Masakiyo Sasahara , Hisao Nishijo * 1 System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 2 Department of Judo Physiotherapy, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 3 Integrative Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 4 Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan Abstract Platelet-derived growth factor (PDGF) is a potent mitogen. Extensive in vivo studies of PDGF and its receptor (PDGFR) genes have reported that PDGF plays an important role in embryogenesis and development of the central nervous system (CNS). Furthermore, PDGF and the b subunit of the PDGF receptor (PDGFR-b) have been reported to be associated with schizophrenia and autism. However, no study has reported on the effects of PDGF deletion on mice behavior. Here we generated novel mutant mice (PDGFR-b KO) in which PDGFR-b was conditionally deleted in CNS neurons using the Cre/loxP system. Mice
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