coherence potentials encode simple human sensorimotor behavior相干势编码简单的人类感觉运动行为.pdfVIP

Coherence Potentials Encode Simple Human Sensorimotor Behavior 1 2 1 Dhanya Parameshwaran , Nathan E. Crone , Tara C. Thiagarajan * 1 National Centre for Biological Sciences, TIFR, Bangalore, India, 2 Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Abstract Recent work has shown that large amplitude negative periods in the local field potential (nLFPs) are able to spread in saltatory manner across large distances in the cortex without distortion in their temporal structure forming ‘coherence potentials’. Here we analysed subdural electrocorticographic (ECoG) signals recorded at 59 sites in the sensorimotor cortex in the left hemisphere of a human subject performing a simple visuomotor task (fist clenching and foot dorsiflexion) to understand how coherence potentials arising in the recordings relate to sensorimotor behavior. In all behaviors we found a particular coherence potential (i.e. a cascade of a particular nLFP wave pattern) arose consistently across all trials with temporal specificity. During contrateral fist clenching, but not the foot dorsiflexion or ipsilateral fist clenching, the coherence potential most frequently originated in the hand representation area in the somatosensory cortex during the anticipation and planning periods of the trial, moving to other regions during the actual motor behavior. While these ‘expert’ sites participated more consistently, other sites participated only a small fraction of the time. Furthermore, the timing of the coherence potential at the hand representation area after onset of the cue predicted the timing of motor behavior. We prese