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biomarkers of immunotoxicity for environmental and public health research生物标记物的免疫毒性对环境和公共健康研究
Int. J. Environ. Res. Public Health 2011, 8, 1388-1401; doi:10.3390/ijerph8051388 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Review Biomarkers of Immunotoxicity for Environmental and Public Health Research Paurene Duramad 1 and Nina T. Holland 2,* 1 Genentech, Inc., 1 DNA Way MS #59, South San Francisco, CA 94080, USA; E-Mail: paurened@ 2 School of Public Health, University of California, Berkeley, 733 University Hall, Berkeley, CA 94720-7360, USA * Author to whom correspondence should be addressed; E-Mail: ninah@. Received: 18 February 2011; in revised form: 26 March 2011 / Accepted: 25 April 2011 / Published: 6 May 2011 Abstract: The immune response plays an important role in the pathophysiology of numerous diseases including asthma, autoimmunity and cancer. Application of biomarkers of immunotoxicity in epidemiology studies and human clinical trials can improve our understanding of the mechanisms that underlie the associations between environmental exposures and development of these immune-mediated diseases. Immunological biomarkers currently used in environmental health studies include detection of key components of innate and adaptive immunity (e.g., complement, immunoglobulin and
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