biomarkers for clinical and incipient tuberculosis performance in a tb-endemic country结核病生物标志物的临床和初始性能;在结核病流行的国家.pdfVIP
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biomarkers for clinical and incipient tuberculosis performance in a tb-endemic country结核病生物标志物的临床和初始性能;在结核病流行的国家
Biomarkers for Clinical and Incipient Tuberculosis: Performance in a TB-Endemic Country 1. 5. 2 3 7 4 Ajay Wanchu , Yuxin Dong , Sunil Sethi , V. P. Myneedu , Arthur Nadas , Zhentong Liu , John Belisle4, Suman Laal5,6,8* 1 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 2 Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 3 Department of Microbiology, Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, New Delhi, India, 4 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America, 5 Department of Pathology, New York University School of Medicine, New York, New York, United States of America, 6 Department of Microbiology, New York University School of Medicine, New York, New York, United States of America, 7 Institute of Environmental Medicine, New York University School of Medicine, New York, New York, United States of America, 8 Veterans Affairs Medical Center, New York, New York, United States of America Abstract 2 + + + Background: Simple biomarkers are required to identify TB in both HIV TB and HIV TB patients. Earlier studies have identified the M. tuberculosis Malate Synthase (MS) and MPT51 as immunodominant antigens in TB patients. One goal of these investigations was to evaluate the sensitivity and specificity of anti-MS and –MPT51 antibodies as biomarkers for TB in HIV2 + + + TB and HIV TB patients from a TB-endemic setting.
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