biodegradation study of microcrystalline chitosan and microcrystalline chitosanβ-tcp complex composites生物降解的研究微晶壳聚糖和微晶chitosanβ-tcp复杂的复合材料.pdfVIP
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biodegradation study of microcrystalline chitosan and microcrystalline chitosanβ-tcp complex composites生物降解的研究微晶壳聚糖和微晶chitosanβ-tcp复杂的复合材料
Int. J. Mol. Sci. 2012, 13, 7617-7628; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites Luciano Pighinelli *, Magdalena Kucharska, Maria Wísniewska-Wrona, Bogdan Gruchała and Kinga Brzoza-Malczewska Institute of Biopolymers and Chemical Fibers—IBWCh, Sklodowskiej-Curie 19/27, Lodz, 90-570, Poland; E-Mails: m.kucharska@ibwch.lodz.pl (M.K.); majka.wrona@op.pl (M.W.-W.); biomater@ibwch.lodz.pl (B.G.); brzozak@poczta.onet.pl (K.B.-M.) * Author to whom correspondence should be addressed; E-Mail: pighinelli@; Tel.: +42-6376-744; Fax: +42-6376-214. Received: 18 April 2012; in revised form: 25 May 2012 / Accepted: 30 May 2012 / Published: 21 June 2012 Abstract: Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. This study compares the biodegradation process, bioactivity, structure, morphology, and mechanical properties of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex; the la
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