xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia氙气和七氟醚提供镇痛期间劳动和在围产期胎儿大脑保护分的大鼠模型.pdfVIP

Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia 1,2,3 1 ´ 1 1 3 3 Ting Yang , Lei Zhuang , Antonio M. Rei Fidalgo , Evgenia Petrides , Niccolo Terrando , Xinmin Wu , 1 4 5 3 1 Robert D. Sanders , Nicola J. Robertson , Mark R. Johnson , Mervyn Maze , Daqing Ma * 1 Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom, 2 Department of Anesthesia and Intensive Care, Beijing University, The First Hospital, Beijing, China, 3 Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America, 4 Neonatology, Institute for Women’s Health, University College London, London, United Kingdom, 5 Reproductive Biology, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom Abstract It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women use some form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective when used as analgesics at subanesthetic concentrations. In this study we sought to understand the effects of two anesthetic agents with presumptive analgesic activity and known preconditioning-neuroprotective properties (sevoflurane or xenon), in reducing hypoxia-induced brain damage in a model of intrauterine p