biodegradable and biocompatible biomaterial, polyhydroxybutyrate, produced by an indigenous vibrio sp. bm-1 isolated from marine environmentpolyhydroxybutyrate可生物降解和生物相容性的生物材料,由一个土著弧菌。bm-1孤立的从海洋环境.pdfVIP

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biodegradable and biocompatible biomaterial, polyhydroxybutyrate, produced by an indigenous vibrio sp. bm-1 isolated from marine environmentpolyhydroxybutyrate可生物降解和生物相容性的生物材料,由一个土著弧菌。bm-1孤立的从海洋环境.pdf

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biodegradable and biocompatible biomaterial, polyhydroxybutyrate, produced by an indigenous vibrio sp. bm-1 isolated from marine environmentpolyhydroxybutyrate可生物降解和生物相容性的生物材料,由一个土著弧菌。bm-1孤立的从海洋环境

Mar. Drugs 2011, 9, 615-624; doi:10.3390/md9040615 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Biodegradable and Biocompatible Biomaterial, Polyhydroxybutyrate, Produced by an Indigenous Vibrio sp. BM-1 Isolated from Marine Environment Yu-Hong Wei 1,*, Wei-Chuan Chen 1, Ho-Shing Wu 2 and Om-Murugan Janarthanan 1 1 Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Chung-Li, Taoyuan 320, Taiwan; E-Mails: itispay@ (W.-C.C.); murugan_jana@yahoo.co.in (O.-M.J.) 2 Department of Chemical Engineering and Material Science, Yuan Ze University, Chung-Li, Taoyuan 320, Taiwan; E-Mail: cehswu@.tw * Author to whom correspondence should be addressed; E-Mail: yhwei@.tw; Tel.: +886-3-4638800; Fax: +886-3-4334667. Received: 8 March 2011; in revised form: 31 March 2011 / Accepted: 12 April 2011 / Published: 18 April 2011 Abstract: Polyhydroxybutyrate (PHB) is one of the polyhydroxyalkanoates (PHAs) which has biodegradable and biocompatible properties. They are adopted in the biomedical field, in, for example, medical implants and drug delivery carriers. This study seeks to promote the production of PHB by Vibrio sp. BM-1, isolated from a marine environment by improving constituents of medium and implementing an appropriate fermentation strategy. This study successfully developed a glycerol-yeast extract-tryptone (GYT) medium that can facilitate the growth of Vibrio sp. BM-1 and lead to the production of 1.4 g/L PHB at 20 h cultivation. This study also shows that 1.57 g/L PHB concentration and 16%