biodegradable tri-block copolymer poly(lactic acid)-poly(ethylene glycol)-poly(l-lysine)(pla-peg-pll) as a non-viral vector to enhance gene transfection可生物降解tri-block共聚物聚(乳酸)聚(乙二醇)聚(赖氨酸)(pla-peg-pll)作为病毒性载体来提高基因转染.pdfVIP

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biodegradable tri-block copolymer poly(lactic acid)-poly(ethylene glycol)-poly(l-lysine)(pla-peg-pll) as a non-viral vector to enhance gene transfection可生物降解tri-block共聚物聚(乳酸)聚(乙二醇)聚(赖氨酸)(pla-peg-pll)作为病毒性载体来提高基因转染.pdf

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biodegradable tri-block copolymer poly(lactic acid)-poly(ethylene glycol)-poly(l-lysine)(pla-peg-pll) as a non-viral vector to enhance gene transfection可生物降解tri-block共聚物聚(乳酸)聚(乙二醇)聚(赖氨酸)(pla-peg-pll)作为病毒性载体来提高基因转染

Int. J. Mol. Sci. 2011, 12, 1371-1388; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Biodegradable Tri-Block Copolymer Poly(lactic acid)- poly(ethylene glycol)-poly(L-lysine)(PLA-PEG-PLL) as a Non-Viral Vector to Enhance Gene Transfection Chunhua Fu 2,†, Xiaoli Sun 1,†, Donghua Liu 1, Zhijing Chen 1, Zaijun Lu 3 and Na Zhang 1,* 1 School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, Ji’nan, 250012 Shandong Province, China; E-Mails: xiaolisun2008@ (X.S.); donghua0209@163.com (D.L.); czjn2001@ (Z.C.) 2 Department of Pharmacy, Shandong Medical College, 5460 Bicyclic Nan Road, Ji’nan, 250002 Shandong Province, China; E-Mail: Chunhua@163.com (C.F.) 3 School of Chemistry and Chemical Engineering, Shandong University, 27 Shanda Road, 250010 Ji’nan, China; E-Mail: z.lu@ (Z.L.) † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: zhangnancy9@; Tel.: +86-531 Fax: +86-531 Received: 28 December 2010; in revisedform: 29 January 2011 / Accepted: 15 February 2011 / Published: 23 February 2011 Abstract: Low cytotoxicity and high gene transfection efficiency are critical issues in designing current non-viral gene delivery vectors. The purpose of the present work was to synthesize the novel biodegradable poly (lactic acid)-poly(ethylene glycol)-poly(L-lysine) (PLA-PEG-PLL) c