a dominant negative erβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats主导负erβ拼接变异决定的有效性在大鼠卵巢切除术后早期或晚期雌激素治疗.pdfVIP

A Dominant Negative ERb Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats 1,2,3,4 3 3 1 1 2 Jun Ming Wang *, Xu Hou , Samuel Adeosun , Rosanne Hill , Sherry Henry , Ian Paul , Ronald W. 7 2 1 2 7 5,6 Irwin , Xiao-Ming Ou , Steven Bigler , Craig Stockmeier , Roberta Diaz Brinton , Elise Gomez-Sanchez 1 Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 2 Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 3 Program in Neuroscience, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 4 Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 5 GV (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 6 Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 7 Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, United States of America Abstract The molecular mechanisms for the discrepancy in outcome of initiating estrogen therapy (ET) around peri-menopause or several years after menopause in women are unknown. We hypothesize that the level of expression of a dominant negative estrogen receptor (ER) b variant, ER b2, may be a key factor determining the effectiveness of ET in post-