zeranol down-regulates p53 expression in primary cultured human breast cancer epithelial cells through epigenetic modification折仑诺下调p53表达主要通过表观遗传修饰人工培养的乳腺癌上皮细胞.pdfVIP

Int. J. Mol. Sci. 2011, 12, 1519-1532; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Zeranol Down-Regulates p53 Expression in Primary Cultured Human Breast Cancer Epithelial Cells through Epigenetic Modification 1 1 1 1 1 1 1 Weiping Ye , Pingping Xu , Robert Jen , Eric Feng , Saiyi Zhong , Hong Li , Shu-Hong Lin , Jie-Yu Liu 1 and Young C. Lin 1,2,* 1 Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA; E-Mails: ye.44@ (W.Y.); xu.200@ (P.X.); jenrt@ (R.J.); fanx40@ (E.F.); zhong.66@ (S.Z.); li.801@ (H.L.); lin.833@ (S.-H.L.); liu.1048@ (J.-Y.L.) 2 333 Goss Laboratory, 1925 Coffey Road, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA * Author to whom correspondence should be addressed; E-Mail: lin.15@; Tel.: +1-614-292-9607; Fax: +1-614-292-6473. Received: 25 January 2011; in revised from: 30 January 2011 / Accepted: 12 February 2011 / Published: 25 February 2011 Abstract: Epidemiological studies have suggested that there are many risk factors associated with breast cancer. Silencing tumor suppressor genes through epigenetic alterations play critical roles in breast cancer initiation, promotion and progression. As a g