zebrafish provegf-c expression, proteolytic processing and inhibitory effect of unprocessed provegf-c during fin regeneration斑马鱼provegf-c表达,蛋白水解处理和未处理的抑制作用期间provegf-c鳍再生.pdfVIP
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zebrafish provegf-c expression, proteolytic processing and inhibitory effect of unprocessed provegf-c during fin regeneration斑马鱼provegf-c表达,蛋白水解处理和未处理的抑制作用期间provegf-c鳍再生
Zebrafish ProVEGF-C Expression, Proteolytic Processing and Inhibitory Effect of Unprocessed ProVEGF-C during Fin Regeneration 1 1,2 1 ´ 3 4 Abdel-Majid Khatib , Rachid Lahlil , Nathalie Scamuffa , Marie-Andree Akimenko , Sylvain Ernest , 5 1 6 7 1 Abdderahim Lomri , Claude Lalou , Nabil G. Seidah , Bruno O. Villoutreix , Fabien Calvo , Geraldine Siegfried2* ´ ´ ´ ˆ ´ 1 INSERM, UMRS940, Equipe Avenir. Institut de Genetique Moleculaire, Hopital St-Louis, Universite Paris 7, Paris, France, 2 INSERM U 770, Kremlin-Bicetre, France, 3 Ottawa ´ ´ ` Health Research Institute, Ottawa, Ontario, Canada, 4 INSERM, U 784, Ecole Normale Superieure, Paris, France, 5 INSERM U 606, Universite Paris 7, Lariboisiere Hospital, ´ Paris, France, 6 Clinical Research Institute of Montreal, IRCM, Montreal, Quebec, Canada, 7 INSERM U648, Universite Paris 5, Paris, France Abstract Background: In zebrafish, vascular endothelial growth factor-C precursor (proVEGF-C) processing occurs within the dibasic motif HSIIRR214 suggesting the involvement of one or more basic amino acid-specific proprotein convertases (PCs) in this process. In the present study, we examined zebrafish proVEGF-C expression and processing and the effect of unprocessed proVEGF-C on caudal fin regeneration. Met
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