the bone-protective effect of genistein in the animal model of bilateral ovariectomy roles of phytoestrogens and pthpthr1 against post-menopausal osteoporosis染料木素的预防骨质疏松效果在动物模型的双边植物雌激素的卵巢切除术角色和pthpthr1对绝经后骨质疏松症.pdfVIP

Int. J. Mol. Sci. 2012, 13, 56-70; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article The Bone-Protective Effect of Genistein in the Animal Model of Bilateral Ovariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-Menopausal Osteoporosis Qing Miao 1,†, Jing-Ge Li 1,†, Shan Miao 1,†, Nan Hu 2,†, Jin Zhang 3, Song Zhang 1, Yan-Hua Xie 1, Jian-Bo Wang 1 and Si-Wang Wang 1,* 1 Institute of Materia Medica, Fourth Military Medical University, Xi’an 710032, China; E-Mails: miaoqing@ (Q.M.); lijingge@ (J.-G.L.); miaoshan@ (S.M.); zhangsong801101@163.com (S.Z.); yanhuaxie@ (Y.-H.X.); yyswjb@ (J.-B.W.) 2 Institute of Stomatology, General Hospital of PLA, Beijing 100853, China; E-Mail: beyondstephen@ 3 Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China; E-Mail: jinzisay@ † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: wangsiw@; Tel.: +86-29 Fax: +86-29 Received: 5 September 2011; in revised form: 13 November 2011 / Accepted: 7 December 2011 / Published: 22 December 2011 Abstract: Genistein, a major phytoestrogen of soy, is considered a potential drug for the prevention and treatment of post-menopausal osteoporosis. Mounting evidence suggested a positive correlation between genistein consumption and bone health both in vivo and in vitro. Earlier stu