the brain matures with stronger functional connectivity and decreased randomness of its network大脑的成熟功能连通性和减少随机性较强的网络.pdfVIP

The Brain Matures with Stronger Functional Connectivity and Decreased Randomness of Its Network 1,3 2 4 5 1,3,6 Dirk J. A. Smit *, Maria Boersma , Hugo G. Schnack , Sifis Micheloyannis , Dorret I. Boomsma , Hilleke E. Hulshoff Pol4, Cornelis J. Stam2,3, Eco J. C. de Geus1,3,6 1 Biological Psychology, VU University, Amsterdam, The Netherlands, 2 Clinical Neurophysiology, VU Medical Centre, Amsterdam, The Netherlands, 3 Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands, 4 Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands, 5 Clinical ´ Neurophysiology Laboratory L Widen, University of Crete, Iraklion, Greece, 6 EMGO+ Institute, VU Medical Centre, Amsterdam, The Netherlands Abstract We investigated the development of the brain’s functional connectivity throughout the life span (ages 5 through 71 years) by measuring EEG activity in a large population-based sample. Connectivity was established with Synchronization Likelihood. Relative randomness of the connectivity patterns was established with Watts and Strogatz’ (1998) graph parameters C (local clustering) and L (global path length) for alpha (,10 Hz), beta (,20 Hz), and theta (,4 Hz) oscillation networks. From childhood to adolescence large increases in connectivity in alpha, theta and beta frequency bands were found that continued at a slower pace into adulthood (peaking at ,50 yrs). Connectivity changes were accompanied by increases in L and C reflecting decreases in network randomness or increased order (peak levels reached at ,18 yrs). Older age (55+