有哪些信誉好的足球投注网站sporadic meningioangiomatosis-associated atypical meningioma mimicking parenchymal invasion of brain a case report and review of the literature零星meningioangiomatosis-associated非典型脑膜瘤模仿实质入侵大脑一个病例报告和文献之回顾.pdfVIP
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sporadic meningioangiomatosis-associated atypical meningioma mimicking parenchymal invasion of brain a case report and review of the literature零星meningioangiomatosis-associated非典型脑膜瘤模仿实质入侵大脑一个病例报告和文献之回顾
Chen et al. Diagnostic Pathology 2010, 5:39 /content/5/1/39 C A S E R E P O R T Open Access Case Report Sporadic meningioangiomatosis-associated atypical meningioma mimicking parenchymal invasion of brain: a case report and review of the literature 1 2 1 3 4 Yan-yang Chen , Xiao-ying Tiang , Zhi Li* , Bo-ning Luo and Quan Huang Abstract Meningioangiomatosis is a rare hamartomatous lesion or meningiovascular malformation in brain. In extremely rare condition, meningioma may occur together with meningioangiomatosis, and only 19 cases have been described in English literature until now. We now report a case of meningioangiomatosis-associated meningioma with atypical and clear cell variant. A 34-year-old man presented a 3-month history of progressive numbness and weakness of his left lower extremity. He had no stigmata of neurofibromatosis type 2. Magnetic resonance imaging (MRI) revealed multifocal lesions in the right frontoparietal lobe. The lesions were totally removed. Microscopically, parts of lesions were atypical and clear cell meningioma corresponding to WHO grade II. The adjacent brain parenchyma showed the histological features of meningioangiomatosis. Neoplastic cells in atypical meningioma area were immunoreactive to epithelial membrane antigen (EMA) with high MIB-1 index of up to 20%. However, the spindle cells in meningioangiomatosis area were negative for EMA with low MIB-1 index of up to 1%. The diagnosis of atypical meningioma associated with sporadic meningioangiomatosis was made. To our knowledge, this is the first case of a meningioangiomatosis-associated meningioma with atypical and clear cell variant component to be described. The patient had been followed-up for 11 months without adjuvant radiotherapy or chemo
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