spotlight on human ll-37, an immunomodulatory peptide with promising cell-penetrating properties的免疫调节肽关注人类ll-37承诺cell-penetrating属性.pdfVIP
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spotlight on human ll-37, an immunomodulatory peptide with promising cell-penetrating properties的免疫调节肽关注人类ll-37承诺cell-penetrating属性
Pharmaceuticals 2010, 3, 3435-3460; doi:10.3390/ph3113435 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties Michèle Seil 1, Carole Nagant 1, Jean-Paul Dehaye 1, Michel Vandenbranden 2 and Marc Ferdinand Lensink 3,* 1 Laboratoire de Chimie Biologique et Médicale et de Microbiologie Pharmaceutique, Institut de Pharmacie, Université Libre de Bruxelles, Boulevard du Triomphe, CP 205/3, B-1050 Brussels, Belgium 2 Laboratoire de Structure et Fonction des Membranes Biologiques, Faculté des Sciences, Université Libre de Bruxelles, Boulevard du Triomphe, CP 206/2, B-1050 Brussels, Belgium 3 Biological Nanosystems, Interdisciplinary Research Institute, University of Sciences and Technology Lille, USR3078 CNRS, 50 Avenue Halley, F-59658 Villeneuve d’Ascq, France * Author to whom correspondence should be addressed; E-Mail: Marc.Lensink@iri.univ-lille1.fr; Tel.: +33-3-6253-1733; Fax: +33-3-6253-1701. Received: 4 October 2010; in revised form: 23 October 2010 / Accepted: 29 October 2010 / Published: 1 November 2010 Abstract: Cationic antimicrobial peptides are major components of innate immunity and help control the initial steps of the infectious process. They are expressed not only by immunocytes, but also by epithelial cells. They share an amphipathic secondary structure with a polar cationic site, which explains their tropism for prokaryote membranes and their hydrophobic site contributing to the destructurat
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