antioxidant and hepatoprotective effects of the red ginseng essential oil in h2o2-treated hepg2 cells and ccl4-treated mice抗氧化剂和王亚南效果的红参精油h2o2-treated hepg2细胞和ccl4-treated老鼠.pdfVIP

antioxidant and hepatoprotective effects of the red ginseng essential oil in h2o2-treated hepg2 cells and ccl4-treated mice抗氧化剂和王亚南效果的红参精油h2o2-treated hepg2细胞和ccl4-treated老鼠.pdf

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antioxidant and hepatoprotective effects of the red ginseng essential oil in h2o2-treated hepg2 cells and ccl4-treated mice抗氧化剂和王亚南效果的红参精油h2o2-treated hepg2细胞和ccl4-treated老鼠

Int. J. Mol. Sci. 2012, 13, 2314-2330; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Antioxidant and Hepatoprotective Effects of the Red Ginseng Essential Oil in H O -Treated HepG2 Cells and 2 2 CCl -Treated Mice 4 Min-Ji Bak 1,†, Mira Jun 2,† and Woo-Sik Jeong 1,* 1 Institute for Phytochemical-Drug Interactions, Department of Food Life Sciences, College of Biomedical Science Engineering, Inje University, Gimhae 621-749, Korea; E-Mail: redapplemj@ 2 Department of Food Science Nutrition, Dong-A University, Busan 604-714, Korea; E-Mail: mjun@dau.ac.kr † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: jeongws@inje.ac.kr; Tel.: +82-55-320-3238; Fax: +82-55-320-0691. Received: 19 December 2011; in revised form: 10 February 2012 / Accepted: 14 February 2012 / Published: 21 February 2012 Abstract: The aim of this study was to evaluate the antioxidant mechanisms of red ginseng essential oil (REO) in cells as well as in an animal model. REO was prepared by a supercritical CO extraction of waste-products generated after hot water extraction of red 2 ginseng. In HepG2 cells, REO diminished the H O -mediated oxidative stress and also

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