有哪些信誉好的足球投注网站androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics通过睾丸雄激素作用小动脉平滑肌细胞对睾丸间质细胞的功能很重要,vasomotion和睾丸流体动力学.pdfVIP
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androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics通过睾丸雄激素作用小动脉平滑肌细胞对睾丸间质细胞的功能很重要,vasomotion和睾丸流体动力学
Androgen Action via Testicular Arteriole Smooth Muscle
Cells Is Important for Leydig Cell Function, Vasomotion
and Testicular Fluid Dynamics
1 1 1 2 1
Michelle Welsh , Richard M. Sharpe , Lindsey Moffat , Nina Atanassova , Philippa T. K. Saunders , Sigrid
3 3 1
Kilter , Anders Bergh , Lee B. Smith *
1 Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen’s Medical Research Institute, Edinburgh, United Kingdom,
2 Institute of Experimental Morphology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria, 3 Department of Anatomy and Pathology,
˚ ˚
University of Umea, Umea, Sweden
Abstract
Regulation of blood flow through the testicular microvasculature by vasomotion is thought to be important for normal
testis function as it regulates interstitial fluid (IF) dynamics which is an important intra-testicular transport medium.
Androgens control vasomotion, but how they exert these effects remains unclear. One possibility is by signalling via
androgen receptors (AR) expressed in testicular arteriole smooth muscle cells. To investigate this and determine the overall
importance of this mechanism in testis function, we generated a blood vessel smooth muscle cell-specific AR knockout
mouse (SMARKO). Gross reproductive development was normal in SMARKO mice but testis weight was reduced in
adulthood compared to control littermates; this reduction was not due to any changes in germ cell volume or to deficits in
testosterone,
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