angiogenic factors in women ten years after severe very early onset preeclampsia血管生成因子在女性十年后严重的早期发生子痫前期.pdfVIP

Angiogenic Factors in Women Ten Years after Severe Very Early Onset Preeclampsia 1 2 2 3 4 Ingrid P. M. Gaugler-Senden *, Jouke T. Tamsma , Chris van der Bent , Ron Kusters , Eric A. P. Steegers , Christianne J. M. de Groot5 1 Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands, 2 Department of Endocrinology and Gastro Intestinal Medicine, Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands, 3 Department of Clinical Chemistry, Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands, 4 Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands, 5 Department of Obstetrics and Gynecology, VU Medical Center, Amsterdam, The Netherlands Abstract Background: Women with a history of mainly severe and early onset preeclampsia have an increased risk of future cardiovascular disease. During these complicated pregnancies increased levels of anti-angiogenic factors can be found. We hypothesize that women with a history of severe very early onset preeclampsia still have increased levels of these biomarkers years after this pregnancy, resulting in increased risk for cardiovascular disease. Methods: Twenty women with severe early onset preeclampsia before 24 weeks’ gestation, who delivered between 1993– 2003 in a tertiary referral centre and twenty matched controls with uncomplicated pregnancies and healthy term infants, were addressed for participation in the study. Venous plasma samples were analyzed for basic fibroblast growth factor (bFGF), placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (