有哪些信誉好的足球投注网站angiopoietin-like 4 mediates ppar delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubesangiopoietin-like 4介导脂蛋白lipase-dependent ppar三角洲影响脂肪酸吸收而不是在肌管的机会.pdfVIP
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angiopoietin-like 4 mediates ppar delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubesangiopoietin-like 4介导脂蛋白lipase-dependent ppar三角洲影响脂肪酸吸收而不是在肌管的机会
Angiopoietin-Like 4 Mediates PPAR Delta Effect on
Lipoprotein Lipase-Dependent Fatty Acid Uptake but
Not on Beta-Oxidation in Myotubes
1 2,3,4 5 2,6 5
Marius R. Robciuc *, Paulina Skrobuk , Andrey Anisimov , Vesa M. Olkkonen , Kari Alitalo ,
7 2,3,4 1 1
Robert H. Eckel , Heikki A. Koistinen , Matti Jauhiainen , Christian Ehnholm
1 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, 2 Unit of Metabolism, Minerva Foundation Institute for Medical
Research, Helsinki, Finland, 3 Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland, 4 Institute of Clinical Medicine, Faculty
of Medicine, University of Helsinki, Helsinki, Finland, 5 Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Research Programs Unit and
Department of Pathology, University of Helsinki, Helsinki, Finland, 6 Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland, 7 Division of Endocrinology,
Metabolism, and Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States of America
Abstract
Peroxisome proliferator-activated receptor (PPAR) delta is an important regulator of fatty acid (FA) metabolism.
Angiopoietin-like 4 (Angptl4), a multifunctional protein, is one of the major targets of PPAR delta in skeletal muscle cells.
Here we investigated the regulation of Angptl4 and its role in mediating PPAR delta functions using human, rat and mouse
myotube
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