有哪些信誉好的足球投注网站androgen regulation of 5α-reductase isoenzymes in prostate cancer implications for prostate cancer prevention在前列腺癌雄激素调节5α-reductase同功酶对前列腺癌预防的影响.pdfVIP
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Androgen Regulation of 5a-Reductase Isoenzymes in
Prostate Cancer: Implications for Prostate Cancer
Prevention
1¤ 1 2 3 3 3
Jin Li , Zhiyong Ding , Zhengxin Wang , Jing-Fang Lu , Sankar N. Maity , Nora M. Navone ,
3 1 3
Christopher J. Logothetis , Gordon B. Mills , Jeri Kim *
1 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, 2 Department of Cancer Biology, The
University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, 3 Department of Genitourinary Medical Oncology, The University of Texas MD
Anderson Cancer Center, Houston, Texas, United States of America
Abstract
The enzyme 5a-reductase, which converts testosterone to dihydrotestosterone (DHT), performs key functions in the
androgen receptor (AR) signaling pathway. The three isoenzymes of 5a-reductase identified to date are encoded by
different genes: SRD5A1, SRD5A2, and SRD5A3. In this study, we investigated mechanisms underlying androgen regulation of
5a-reductase isoenzyme expression in human prostate cells. We found that androgen regulates the mRNA level of 5a-
reductase isoenzymes in a cell type–specific manner, that such regulation occurs at the transcriptional level, and that AR is
necessary for this regulation. In addition, our results suggest that AR is recruited to a negative androgen response element
(nARE) on the promoter of SRD5A3 in vivo and directly binds to the nARE in vitro. The different expression levels of 5a-
reductase isoenzymes may confer response or resistance to 5a-reductase inhibitors and thus may have importance in
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