有哪些信誉好的足球投注网站an antibody to de-n-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines抗体de-n-acetyl唾液酸containing-polysialic酸标识一个细胞内抗原,在人类癌症细胞系凋亡.pdfVIP
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an antibody to de-n-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines抗体de-n-acetyl唾液酸containing-polysialic酸标识一个细胞内抗原,在人类癌症细胞系凋亡
An Antibody to De-N-Acetyl Sialic Acid Containing-
Polysialic Acid Identifies an Intracellular Antigen and
Induces Apoptosis in Human Cancer Cell Lines
1 1,2
Lindsay M. Steirer , Gregory R. Moe *
1 Centers for Cancer, Children’s Hospital Oakland Research Institute (CHORI), Oakland, California, United States of America, 2 Immunobiology and Vaccine Development,
Children’s Hospital Oakland Research Institute (CHORI), Oakland, California, United States of America
Abstract
Polysialic acid (PSA), an a2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its
expression is thought to be restricted to a few tissues in adults. Recently, we showed that two human pathogens expressed
a derivative of PSA containing de-N-acetyl sialic acid residues (NeuPSA). Here we show that an epitope identified by the
anti-NeuPSA monoclonal antibody, SEAM 3 (SEAM 3-reactive antigen or S3RA), is expressed in human melanomas, and also
intracellularly in a human melanoma cell line (SK-MEL-28), a human T cell leukemia cell line (Jurkat), and two neuroblastoma
cell lines (CHP-134 and SH-SY5Y). SEAM 3 binding induced apoptosis in the four cell lines tested. The unusual intracellular
distribution of S3RA was similar to that described for the PSA polysialyltransferases, STX and PST, which are also expressed
in the four cell lines used here. Interestingly, suppression of PST mRNA expression by transfection of SK-MEL-28 cells with
PST-specific short interfering RNA (siRNA) resulted in decreased SEAM 3 binding. The results suggest further studies of the
utility of antibodies such as SEAM 3 as therapeutic agents for certain malignancies.
Citation: Steirer LM, Moe GR (2011) An Antibody to De-N-Acetyl Sialic Acid Containing-Polysialic Acid Identifies an Intracellular Antigen and Induces Apoptosis in
Human C
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