an autism-associated variant of epac2 reveals a role for rasepac2 signaling in controlling basal dendrite maintenance in miceepac2揭示角色的自闭症相关变体rasepac2信号在控制基底树突维护在老鼠身上.pdfVIP
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an autism-associated variant of epac2 reveals a role for rasepac2 signaling in controlling basal dendrite maintenance in miceepac2揭示角色的自闭症相关变体rasepac2信号在控制基底树突维护在老鼠身上
An Autism-Associated Variant of Epac2 Reveals a Role for
Ras/Epac2 Signaling in Controlling Basal Dendrite
Maintenance in Mice
1,2. 1. 1 1 1
Deepak P. Srivastava , Kevin M. Woolfrey , Kelly A. Jones , Charles T. Anderson , Katharine R. Smith ,
1 3 4 1 4,5,6
Theron A. Russell , Hyerin Lee , Marina V. Yasvoina , David L. Wokosin , P. Hande Ozdinler ,
Gordon M. G. Shepherd1, Peter Penzes1,6,7*
1 Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, 2 Department of Neuroscience Centre for
the Cellular Basis of Behaviour, The James Black Centre, King’s College London, Institute of Psychiatry, London, United Kingdom, 3 Weinberg College of Arts and Sciences,
Northwestern University, Evanston, Illinois, United States of America, 4 Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago,
Illinois, United States of America, 5 Cognitive Neurology and Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of
America, 6 Lurie Cancer Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, 7 Department of Psychiatry and
Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
Abstract
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computational properties of
neurons, and dendritic structure is impaired in several psychia
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