an assessment of the interindividual variability of internal dosimetry during multi-route exposure to drinking water contaminants评估期间内部剂量测定法的个人间变异性multi-route接触饮用水污染物.pdfVIP
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an assessment of the interindividual variability of internal dosimetry during multi-route exposure to drinking water contaminants评估期间内部剂量测定法的个人间变异性multi-route接触饮用水污染物
Int. J. Environ. Res. Public Health 2010, 7, 4002-4022; doi:10.3390/ijerph7114002
OPEN ACCESS
International Journal of
Environmental Research and
Public Health
ISSN 1660-4601
/journal/ijerph
Article
An Assessment of the Interindividual Variability of Internal
Dosimetry during Multi-Route Exposure to Drinking Water
Contaminants
Mathieu Valcke 1,2 and Kannan Krishnan 1,*
1 Département de santé environnementale et santé au travail, Université de Montréal, CP 6128,
Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada;
E-Mail: mathieu.valcke@inspq.qc.ca
2 Institut national de santé publique du Québec, 190 Boulevard Crémazie Est, Montréal, Québec,
H2P 1E2, Canada
* Author to whom correspondence should be addressed; E-Mail: kannan.krishnan@umontreal.ca;
Tel.: +1-514-343-6581; Fax: +1-514-343-2200.
Received: 9 October 2010; in revised form: 4 November 2010 / Accepted: 12 November 2010 /
Published: 17 November 2010
Abstract: The objective of this study was to evaluate inter-individual variability in
absorbed and internal doses after multi-route exposure to drinking water contaminants
(DWC) in addition to the corresponding variability in equivalent volumes of ingested
water, expressed as liter-equivalents (LEQ). A multi-route PBPK model described
previously was used for compu
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