adoptive transfer of induced-treg cells effectively attenuates murine airway allergic inflammationinduced-treg细胞过继转移有效减弱小鼠气道过敏性炎症.pdfVIP

Adoptive Transfer of Induced-Treg Cells Effectively Attenuates Murine Airway Allergic Inflammation 1,4. 2,3. 2 1 2 2,3 2 3 Wei Xu , Qin Lan , Maogen Chen , Hui Chen , Ning Zhu , Xiaohui Zhou , Julie Wang , Huimin Fan , 4 4 1 ´ 5 5 Chun-Song Yan , Jiu-Long Kuang , David Warburton , Dieudonnee Togbe , Bernhard Ryffel , Song- 2 1 Guo Zheng *, Wei Shi * 1 Developmental Biology and Regenerative Medicine Program, Department of Surgery, Children’s Hospital Los Angeles, Los Angeles, California, United States of America, 2 Division of Rheumatology, Department of Medicine, The Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, 3 Institute of Immunology, Shanghai East Hospital of Tongji University, Shanghai, China, 4 Department of Respiratory Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China, 5 Molecular Immunology, University and CNRS, Orleans, France Abstract Both nature and induced regulatory T (Treg) lymphocytes are potent regulators of autoimmune and allergic disorders. Defects in endogenous Treg cells have been reported in patients with allergic asthma, suggesting that disrupted Treg cell- mediated immunological regulation may play an important role in airway allergic inflammation. In order to determine whether adoptive transfer of induced Treg cells generated in vitro can be used as an effective therapeutic approach to suppress airway allergic inflammation, exogenously induced Treg ce