有哪些信誉好的足球投注网站aberrant expression of oncogenic and tumor-suppressive micrornas in cervical cancer is required for cancer cell growth致癌基因的异常表达与肿瘤抑制小分子核糖核酸宫颈癌是癌症细胞生长所必需的.pdfVIP
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aberrant expression of oncogenic and tumor-suppressive micrornas in cervical cancer is required for cancer cell growth致癌基因的异常表达与肿瘤抑制小分子核糖核酸宫颈癌是癌症细胞生长所必需的
Aberrant Expression of Oncogenic and Tumor-
Suppressive MicroRNAs in Cervical Cancer Is Required for
Cancer Cell Growth
1. 1. 2 1 3 4
Xiaohong Wang , Shuang Tang , Shu-Yun Le , Robert Lu , Janet S. Rader , Craig Meyers , Zhi-Ming
Zheng1*
1 HIV and AIDS Malignancy Branch, Center for Cancer Research, Nation Cancer Institute (NCI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of
America, 2 Nanobiology Program, Center for Cancer Research, Nation Cancer Institute (NCI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of
America, 3 Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Department of
Microbiology and Immunology, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America
Abstract
MicroRNAs (miRNAs) play important roles in cancer development. By cloning and sequencing of a HPV16+ CaSki cell small
RNA library, we isolated 174 miRNAs (including the novel miR-193c) which could be grouped into 46 different miRNA
species, with miR-21, miR-24, miR-27a, and miR-205 being most abundant. We chose for further study 10 miRNAs according
to their cloning frequency and associated their levels in 10 cervical cancer- or cervical intraepithelial neoplasia-derived cell
lines. No correlation was observed between their expression with the presence or absence of an integrated or episomal HPV
genome. All cell lines examined contained no detectable miR-143 and miR-145. HPV-infected cell lines expressed a different
set of miRNAs when grown in organotypic raft cultured as compared to monolayer cell culture, including expression of miR-
143 and miR-145
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