有哪些信誉好的足球投注网站activation of pi3kakt and mapk pathway through a pdgfrβ-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma激活pi3kakt和mapk通路通过pdgfrβ-dependent反馈回路参与在肝细胞癌雷帕霉素抵抗.pdfVIP
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activation of pi3kakt and mapk pathway through a pdgfrβ-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma激活pi3kakt和mapk通路通过pdgfrβ-dependent反馈回路参与在肝细胞癌雷帕霉素抵抗
Activation of PI3K/AKT and MAPK Pathway through a
PDGFRb-Dependent Feedback Loop Is Involved in
Rapamycin Resistance in Hepatocellular Carcinoma
1,2. 1. 1. 1. 2 1
Quan-Lin Li , Fang-Ming Gu , Zheng Wang , Jia-Hao Jiang , Li-Qing Yao , Chang-Jun Tan ,
1 1 1,3 1,3 1,3
Xiao-Yong Huang , Ai-Wu Ke , Zhi Dai , Jia Fan *, Jian Zhou *
1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of
Education, Shanghai, People’s Republic of China, 2 Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, People’s
Republic of China, 3 Shanghai Key Laboratory of Organ Transplantation, Shanghai, People’s Republic of China
Abstract
Background: Rapamycin is an attractive approach for the treatment and prevention of HCC recurrence after liver
transplantation. However, the objective response rates of rapamycin achieved with single-agent therapy were modest,
supporting that rapamycin resistance is a frequently observed characteristic of many cancers. Some studies have been
devoted to understanding the mechanisms of rapamycin resistance, however, the mechanisms are cell-type-dependent and
studies on rapamycin resistance in HCC are extremely limited.
Methodology/Principal Findings: The anti-tumor sensitivity of rapamycin was modest in vitro and in vivo. In both human
and rat HCC cells, rapamycin up-regulated the expression and phosphorylation of PDGFRb in a time and dose-depende
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