activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats激活过氧物酶体proliferator-activated受体γ,罗格列酮增加sirt6表达和改善大鼠肝脏脂肪变性.pdfVIP

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activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats激活过氧物酶体proliferator-activated受体γ,罗格列酮增加sirt6表达和改善大鼠肝脏脂肪变性.pdf

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activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats激活过氧物酶体proliferator-activated受体γ,罗格列酮增加sirt6表达和改善大鼠肝脏脂肪变性

Activation of Peroxisome Proliferator-Activated Receptor Gamma by Rosiglitazone Increases Sirt6 Expression and Ameliorates Hepatic Steatosis in Rats 1 1 2 3 3 3 Soo Jin Yang , Jung Mook Choi , Seoung Wan Chae , Won Jun Kim , Se Eun Park , Eun Jung Rhee , Won 3 3 3 3 3 Young Lee , Ki Won Oh , Sung Woo Park , Sun Woo Kim , Cheol-Young Park * 1 Diabetes Research Institute, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea, 2 Department of Pathology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea, 3 Department of Endocrinology and Metabolism, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea Abstract Background: Sirt6 has been implicated in the regulation of hepatic lipid metabolism and the development of hepatic steatosis. The aim of this study was to address the potential role of Sirt6 in the protective effects of rosiglitazone (RGZ) on hepatic steatosis. Methods: To investigate the effect of RGZ on hepatic steatosis, rats were treated with RGZ (4 mg ?kg21?day21) by stomach gavage for 6 weeks. The involvement of Sirt6 in the RGZ’s regulation was evaluated by Sirt6 knockdown in AML12 mouse hepatocytes. Results: RGZ treatment ameliorated hepatic lipid accumulation and increased expression of Sirt6, peroxisome proliferator- activated receptor gamma coactivtor-1-a (Ppargc1a/PGC1-a) and Forkhead box O1 (Foxo1) in rat livers. AMP-activated protein kinase (AMPK) phosphorylation was also increased by RGZ, accompanied by alterations in phosphorylation of LKB1. Interestingly, in free fatty acid