有哪些信誉好的足球投注网站a versatile overexpression strategy in the pathogenic yeast candida albicans identification of regulators of morphogenesis and fitness多功能超表达策略在监管机构的白色念珠菌致病酵母鉴定的形态发生和健身.pdfVIP
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a versatile overexpression strategy in the pathogenic yeast candida albicans identification of regulators of morphogenesis and fitness多功能超表达策略在监管机构的白色念珠菌致病酵母鉴定的形态发生和健身
A Versatile Overexpression Strategy in the Pathogenic
Yeast Candida albicans: Identification of Regulators of
Morphogenesis and Fitness
Murielle Chauvel1,2., Audrey Nesseir1,2,3., Vitor Cabral1,2,3, Sadri Znaidi1,2, Sophie Goyard1,2¤a,
1,2 1,2¤b ´ 1,2 ´ 1,2,3¤c
Sophie Bachellier-Bassi , Arnaud Firon , Melanie Legrand , Dorothee Diogo ,
Claire Naulleau1,2¤d, Tristan Rossignol1,2¤e, Christophe d’Enfert1,2*
´ ´ ´ ´ ´ ´ ´ ´
1 Institut Pasteur, Unite Biologie et Pathogenicite Fongiques, Departement Genomes et Genetique, Paris, France, 2 INRA, USC2019, Paris, France, 3 Universite Paris Diderot,
´
Sorbonne Paris Cite, Cellule Pasteur, Paris, France
Abstract
Candida albicans is the most frequently encountered human fungal pathogen, causing both superficial infections and life-
threatening systemic diseases. Functional genomic studies performed in this organism have mainly used knock-out mutants
and extensive collections of overexpression mutants are still lacking. Here, we report the development of a first generation
C. albicans ORFeome, the improvement of overexpression systems and the construction of two new libraries of C. albicans
strains overexpressing genes for components of signaling networks, in particular protein kinases, protein phosphatases and
transcription factors. As a proof of concept, we screened these collections for genes whose overexpression impacts
morphogenesis or growth rates in C. albicans. Our screens identified genes previously described for their role
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