a short receptor downregulates jakstat signalling to control the drosophila cellular immune response短会使受体jakstat信号控制果蝇细胞免疫反应.pdfVIP

a short receptor downregulates jakstat signalling to control the drosophila cellular immune response短会使受体jakstat信号控制果蝇细胞免疫反应.pdf

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a short receptor downregulates jakstat signalling to control the drosophila cellular immune response短会使受体jakstat信号控制果蝇细胞免疫反应

A Short Receptor Downregulates JAK/STAT Signalling to Control the Drosophila Cellular Immune Response Rami Makki1,2¤a., Marie Meister3¤b., Delphine Pennetier1,2, Jean-Michel Ubeda3¤c, Anne Braun3¤d, 1,2 ´ 1,2¤e 1,2 4 1,2 ` Virginie Daburon , Joanna Krzemien , Henri-Marc Bourbon , Rui Zhou , Alain Vincent *, Michele Crozatier1,2* ´ ´ ´ 1 Universite Toulouse 3, Toulouse, France, 2 Centre de Biologie du Developpement UMR5547 CNRS Toulouse, France, 3 Institut de Biologie Moleculaire et Cellulaire, UPR9022 CNRS, Strasbourg, France, 4 Department of Genetics at Harvard Medical School, Boston, Massachusetts, United States of America Abstract The posterior signalling centre (PSC), a small group of specialised cells, controls hemocyte (blood cell) homeostasis in the Drosophila larval hematopoietic organ, the lymph gland. This role of the PSC is very reminiscent of the ‘‘niche,’’ the micro- environment of hematopoietic stem cells in vertebrates. We have recently shown that the PSC acts in a non–cell- autonomous manner to maintain janus tyrosine kinase/signal transducers and activators of transcription (JAK/STAT) signalling in hematopoietic progenitors (prohemocytes), thereby preserving the multipotent character necessary for their differentiation into lamellocytes, a cryptic and dedicated immune cell type required to fight specific immune threats such as wasp parasitism. In this report, on the basis of a knock out generated by homologous recombination, we

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