有哪些信誉好的足球投注网站a whole-genome snp association study of nci60 cell line panel indicates a role of ca2+ signaling in selenium resistance全基因组snp协会nci60细胞系的研究小组表明硒抗钙离子信号的作用.pdfVIP
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awhole-genomesnpassociationstudyofnci60celllinepanelindicatesaroleofca2signalinginseleniumresistance全基因组snp协会nci60细胞系的研究小组表明硒抗钙离子信号的作用
A Whole-Genome SNP Association Study of NCI60 Cell
Line Panel Indicates a Role of Ca2+ Signaling in Selenium
Resistance
1,2,3 4 1,2,3 1,2,3 4
Sevtap Savas , Laurent Briollais , Irada Ibrahim-zada , Hamdi Jarjanazi , Yun Hee Choi , Mireia
5 6 5 1,2,3
Musquera , Neil Fleshner , Vasundara Venkateswaran *, Hilmi Ozcelik *
1 Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, 2 Department of Pathology and
Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, 3 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario,
Canada, 4 Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, Ontario, Canada, 5 Division of Urology, Sunnybrook Health Sciences Centre, Toronto,
Ontario, Canada, 6 Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
Abstract
Epidemiological studies have suggested an association between selenium intake and protection from a variety of cancer.
Considering this clinical importance of selenium, we aimed to identify the genes associated with resistance to selenium
treatment. We have applied a previous methodology developed by our group, which is based on the genetic and
pharmacological data publicly available for the NCI60 cancer cell line panel. In short, we have categorized the NCI60 cell
lines as selenium resistant and sensitive based on their growth inhibition (GI50) data. Then, we have utilized the Affymetrix
125K SNP chip data available and c
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