a single nucleotide polymorphism within dusp9 is associated with susceptibility to type 2 diabetes in a japanese populationdusp9内的单核苷酸多态性与2型糖尿病易感性有关在日本人口.pdfVIP

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a single nucleotide polymorphism within dusp9 is associated with susceptibility to type 2 diabetes in a japanese populationdusp9内的单核苷酸多态性与2型糖尿病易感性有关在日本人口.pdf

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a single nucleotide polymorphism within dusp9 is associated with susceptibility to type 2 diabetes in a japanese populationdusp9内的单核苷酸多态性与2型糖尿病易感性有关在日本人口

A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population 1,2. 1. 2 3 4 5 Hisashi Fukuda , Minako Imamura , Yasushi Tanaka , Minoru Iwata , Hiroshi Hirose , Kohei Kaku , 6 7,8 3 6 8 Hiroshi Maegawa , Hirotaka Watada , Kazuyuki Tobe , Atsunori Kashiwagi , Ryuzo Kawamori , Shiro Maeda1* 1 Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama 230-0045, Japan, 2 Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan, 3 First Department of Internal Medicine, University of Toyama, Toyama, Japan, 4 Health Center, Keio University School of Medicine, Tokyo, Japan, 5 Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan, 6 Department of Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan, 7 Department of Medicine, Metabolism and Endocrinology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan, 8 Sportology Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan Abstract Aims: The DUSP9 locus on chromosome X was identified as a susceptibility locus for type 2 diabetes in a meta-analysis of European genome-wide association studies (GWAS), and GWAS in South Asian populations identified 6 additional single nucleotide polymorphism (SNP) loci for type 2 diabetes. However, the associatio