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a single mutation in chikungunya virus affects vector specificity and epidemic potential单一突变在基孔肯雅病毒影响矢量特异性和流行潜力
A Single Mutation in Chikungunya Virus
Affects Vector Specificity and Epidemic Potential
*
Konstantin A. Tsetsarkin, Dana L. Vanlandingham, Charles E. McGee, Stephen Higgs
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics. The 2005–
2006 epidemic on Reunion island that resulted in approximately 266,000 human cases was associated with a strain of
CHIKV with a mutation in the envelope protein gene (E1-A226V). To test the hypothesis that this mutation in the
epidemic CHIKV (strain LR2006 OPY1) might influence fitness for different vector species, viral infectivity,
dissemination, and transmission of CHIKV were compared in Aedes albopictus, the species implicated in the epidemic,
and the recognized vector Ae. aegypti. Using viral infectious clones of the Reunion strain and a West African strain of
CHIKV, into which either the E1–226 A or V mutation was engineered, we demonstrated that the E1-A226V mutation
was directly responsible for a significant increase in CHIKV infectivity for Ae. albopictus, and led to more efficient viral
dissemination into mosquito secondary organs and transmission to suckling mice. This mutation caused a marginal
decrease in CHIKV Ae. aegypti midgut infectivity, had no effect on viral dissemination, and was associated with a slight
increase in transmission by Ae. aegypti to suckling mice in competition experiments. The effect of the E1-A226V
mutation on cholesterol dependence of CHIKV was also analyzed, revealing an association between cholesterol
dependence and increased fitness of CHIKV in Ae. albopictus. Our observation that a single amino acid subst
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