a small peptide modeled after the nrage repeat domain inhibits xiap-tab1-tak1 signaling for nf-κb activation and apoptosis in p19 cells一个小肽仿照nrage重复域抑制xiap-tab1-tak1 nf-κb激活和p19细胞凋亡的信号.pdfVIP

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2017-09-07 发布于上海
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a small peptide modeled after the nrage repeat domain inhibits xiap-tab1-tak1 signaling for nf-κb activation and apoptosis in p19 cells一个小肽仿照nrage重复域抑制xiap-tab1-tak1 nf-κb激活和p19细胞凋亡的信号.pdf

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a small peptide modeled after the nrage repeat domain inhibits xiap-tab1-tak1 signaling for nf-κb activation and apoptosis in p19 cells一个小肽仿照nrage重复域抑制xiap-tab1-tak1 nf-κb激活和p19细胞凋亡的信号

A Small Peptide Modeled after the NRAGE Repeat Domain Inhibits XIAP-TAB1-TAK1 Signaling for NF-kB Activation and Apoptosis in P19 Cells 1,2,3¤ 2,4 2 2 2 Jennifer A. Rochira , Nicholas N. Matluk , Tamara L. Adams , Aldona A. Karaczyn , Leif Oxburgh , 3 2 Samuel T. Hess , Joseph M. Verdi * 1 IGERT Functional Genomics Ph.D. Program, University of Maine, Orono, Maine, United States of America, 2 Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, United States of America, 3 Department of Physics and Astronomy, University of Maine, Orono, Maine, United States of America, 4 Graduate School of Biomedical Sciences, University of Maine, Orono, Maine, United States of America Abstract In normal growth and development, apoptosis is necessary to shape the central nervous system and to eliminate excess neurons which are not required for innervation. In some diseases, however, apoptosis can be either overactive as in some neurodegenerative disorders or severely attenuated as in the spread of certain cancers. Bone morphogenetic proteins (BMPs) transmit signals for regulating cell growth, differentiation, and apoptosis. Responding to BMP receptors stimulated from BMP ligands, neurotrophin receptor-mediated MAGE homolog (NRAGE) binds and functions with the XIAP-TAK1-TAB1 complex to activate p38MAPK and induces apoptosis in cortical neural progenitors. NRAGE contains a unique repeat domain that is only found in human, mouse, and rat homologs that we theorize is pivotal in its BMP MAPK role. Previously, we showed that deletion of the repeat domain inhibits apoptosis, p38MAPK phosphorylation, and ca