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a single-molecule study on the structural damage of ultraviolet radiated dna单分子研究紫外辐射的结构性破坏dna
Int. J. Mol. Sci. 2008, 9, 662-667
International Journal of
Molecular Sciences
ISSN 1422-0067
© 2008 by MDPI
/ijms
Communication
A Single-Molecule Study on the Structural Damage of
Ultraviolet Radiated DNA
Kathryn Schallhorn 1,2, Mickey Kim 1 and Pu Chun Ke 1,*
1 Laboratory of Single-Molecule Biophysics and Polymer Physics, Clemson University, Clemson,
SC 29634-0978, USA
2 Carl Zeiss MicroImaging, Inc. One Zeiss Drive, Thornwood, NY 10594, USA
* Author to whom correspondence should be addressed. Fax: 864-656-0558;
E-mail: pcke11@
Received: 21 December 2007; in revised form: 22 April 2008 / Accepted: 23 April 2008 /
Published: 24 April 2008
Abstract: The structural damage of double-stranded DNA under UV radiation was
examined using single-molecule fluorescence microscopy. Compared to undamaged DNA,
the diffusion coefficient of λ-DNA was significantly increased with 12 min or 20 min of
radiation but remained unchanged for 40 min of exposure possibly due to strand
crosslinking. The structural damage of DNA was further examined using transmission
electron microscopy which revealed kinks and sharp bends along the DNA backbone.
Keywords: DNA damage; UV radiation; flexibility; diffusion.
1. Introduction
DNA photon absorption, on a time scale of 10-12 sec, can excite a pyrimidine base. In this excited
state, energy can be released through various pathways, such as fluorescence,
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