有哪些信誉好的足球投注网站a simple negative interaction in the positive transcriptional feedback of a single gene is sufficient to produce reliable oscillations一个简单的负作用的积极转录反馈单基因就足以产生可靠的振荡.pdfVIP
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a simple negative interaction in the positive transcriptional feedback of a single gene is sufficient to produce reliable oscillations一个简单的负作用的积极转录反馈单基因就足以产生可靠的振荡
A Simple Negative Interaction in the Positive
Transcriptional Feedback of a Single Gene Is Sufficient to
Produce Reliable Oscillations
´ ´ ´ ´
Jesus M. Miro-Bueno*, Alfonso Rodrıguez-Paton*
´ ´
Departamento de Inteligencia Artificial, Facultad de Informatica, Universidad Politecnica de Madrid, Madrid, Spain
Abstract
Negative and positive transcriptional feedback loops are present in natural and synthetic genetic oscillators. A single gene
with negative transcriptional feedback needs a time delay and sufficiently strong nonlinearity in the transmission of the
feedback signal in order to produce biochemical rhythms. A single gene with only positive transcriptional feedback does
not produce oscillations. Here, we demonstrate that this single-gene network in conjunction with a simple negative
interaction can also easily produce rhythms. We examine a model comprised of two well-differentiated parts. The first is a
positive feedback created by a protein that binds to the promoter of its own gene and activates the transcription. The
second is a negative interaction in which a repressor molecule prevents this protein from binding to its promoter. A
stochastic study shows that the system is robust to noise. A deterministic study identifies that the dynamics of the oscillator
are mainly driven by two types of biomolecules: the protein, and the complex formed by the repressor and this protein. The
main conclusion of this paper is that a simple and usual negative interaction, such as degradation, sequestration or
inhibition, acting on
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