a porcine circovirus type 2 (pcv2) mutant with 234 amino acids in capsid protein showed more virulence in vivo, compared with classical pcv2ab strain猪圆环病毒2型(pcv2)和234个氨基酸突变体衣壳蛋白显示更多的体内毒性,而古典pcv2ab应变.pdfVIP

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a porcine circovirus type 2 (pcv2) mutant with 234 amino acids in capsid protein showed more virulence in vivo, compared with classical pcv2ab strain猪圆环病毒2型(pcv2)和234个氨基酸突变体衣壳蛋白显示更多的体内毒性,而古典pcv2ab应变.pdf

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a porcine circovirus type 2 (pcv2) mutant with 234 amino acids in capsid protein showed more virulence in vivo, compared with classical pcv2ab strain猪圆环病毒2型(pcv2)和234个氨基酸突变体衣壳蛋白显示更多的体内毒性,而古典pcv2ab应变

A Porcine Circovirus Type 2 (PCV2) Mutant with 234 Amino Acids in Capsid Protein Showed More Virulence In Vivo, Compared with Classical PCV2a/b Strain Longjun Guo, Yujie Fu, Yiping Wang, Yuehua Lu, Yanwu Wei, Qinghai Tang, Peihu Fan, Jianbo Liu, Long Zhang, Feiyan Zhang, Liping Huang, Dan Liu, Shengbin Li, Hongli Wu, Changming Liu* Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China Abstract Background: Porcine circovirus type 2 (PCV2) is considered to be the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), which has become a serious economic problem for the swine industry worldwide. The major genotypes, PCV2a and PCV2b, are highly prevalent in the pig population and are present worldwide. However, another newly emerging PCV2b genotype mutant, which has a mutation in its ORF2-encoded capsid protein, has been sporadically present in China, as well as in other countries. It is therefore important to determine the relative virulence of the newly emerging PCV2b genotype mutant, compared with the existing PCV2a and PCV2b genotypes, and to investigate whether the newly emerging mutant virus induces more severe illness. Methodology/Principal Findings: Twenty healthy, 30-day-old, commercial piglets served as controls or were challenged with PCV2a, PCV2b and the newly emerging mutant virus. A series of indexes representing different parameters were adopted to evaluate virulence, including clinical signs, serological detection, viral load and distribution, changes in immune cell subsets in the peripheral blood, and evaluation of pathological lesions. The newly emerging PCV2 mutant demonstrated more severe signs compatible with PMWS, characterized by wasting, coughing, dyspnea, diarrhea, rough hair-c