有哪些信誉好的足球投注网站a panel of serum micrornas as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats一组血清microrna作为诊断特定的生物标记化合物,herb-induced在大鼠肝损伤.pdfVIP
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a panel of serum micrornas as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats一组血清microrna作为诊断特定的生物标记化合物,herb-induced在大鼠肝损伤
A Panel of Serum MicroRNAs as Specific Biomarkers for
Diagnosis of Compound- and Herb-Induced Liver Injury
in Rats
1. 2. 3 4 2 1 2 3
Yu-Wen Su , Xi Chen , Zhen-Zhou Jiang , Tao Wang , Cheng Wang , Yun Zhang , Jing Wen , Mei Xue ,
4 1 2 3 2 1,3,4
Dan Zhu , Yue Zhang , Yi-Jing Su , Tong-Yue Xing , Chen-Yu Zhang *, Lu-Yong Zhang *
1Jiangsu Center of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu Province, China, 2 State Key Laboratory of Pharmaceutical Biotechnology, School of
Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China, 3 Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University,
Ministry of Education, Nanjing, Jiangsu Province, China, 4 Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing,
Jiangsu Province, China
Abstract
Background: Drug-induced liver injury (DILI) has been a public, economic and pharmaceutical issue for many years.
Enormous effort has been made for discovering and developing novel biomarkers for diagnosing and monitoring both
clinical and preclinical DILI at an early stage, though progress has been relatively slow. Additionally, herb-induced liver injury
is an emerging cause of liver disease because herbal medicines are increasingly being used worldwide. Recently, circulating
microRNAs (miRNAs) have shown potential to serve as novel, minimally invasive biomarkers to diagnose and monitor
human cancers and other diseases at early stages.
Methodology/P
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