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a network model for the correlation between epistasis and genomic complexity网络模型之间的关系上位和基因组的复杂性
A Network Model for the Correlation between Epistasis
and Genomic Complexity
´ 1,2,3 4,5
Rafael Sanjuan *, Miguel R. Nebot
` ` ` ` `
1 Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain, 2 Departament de Genetica, Universitat de Valencia, Valencia, Spain,
´ ` ´ ´ ´ ´
3 Instituto de Biologıa Molecular y Celular de Plantas (CSIC-UPV), Valencia, Spain, 4 Centro de Fısica Teorica de Partıculas (CFTP), Instituto Superior Tecnico, Lisboa,
`
Portugal, 5 Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Roma Tre, Dipartimento di Fisica ‘‘Edoardo Amaldi’’, Universita degli Studi Roma Tre, Roma, Italy
Abstract
The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A
general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes
epistasis is antagonistic on average (mutational effects tend to cancel each other out), whereas a transition towards
synergistic epistasis occurs in more complex genomes (mutational effects strengthen each other). Here, we use a simple
network model to identify basic features explaining this correlation. We show that, in small networks with multifunctional
nodes, lack of redundancy, and absence of alternative pathways, epistasis is a
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