a neonatal model of intravenous staphylococcus epidermidis infection in mice 24 h old enables characterization of early innate immune responses静脉epidermidis葡萄球菌感染的新生儿模型小鼠24小时老使早期先天免疫反应的特征.pdfVIP

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a neonatal model of intravenous staphylococcus epidermidis infection in mice 24 h old enables characterization of early innate immune responses静脉epidermidis葡萄球菌感染的新生儿模型小鼠24小时老使早期先天免疫反应的特征.pdf

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a neonatal model of intravenous staphylococcus epidermidis infection in mice 24 h old enables characterization of early innate immune responses静脉epidermidis葡萄球菌感染的新生儿模型小鼠24小时老使早期先天免疫反应的特征

A Neonatal Model of Intravenous Staphylococcus epidermidis Infection in Mice ,24 h Old Enables Characterization of Early Innate Immune Responses 1,2 2 2,3 2,3 Kenny D. Kronforst , Christy J. Mancuso , Matthew Pettengill , Jana Ninkovic , Melanie R. Power 4 2 5 6 6 2,3 Coombs , Chad Stevens , Michael Otto , Carina Mallard , Xiaoyang Wang , Donald Goldmann , Ofer Levy2,3* 1 Newborn Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America, 2 Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, 3 Harvard Medical School, Boston, Massachusetts, United States of America, 4 Pathology, Dalhousie University, Halifax, Nova Scotia, Canada, 5 Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, United States of America, 6 Physiology, The University of Gothenburg, Gothenburg, Sweden Abstract Staphylococcus epidermidis (SE) causes late onset sepsis and significant morbidity in catheterized preterm newborns. Animal models of SE infection are useful in characterizing disease mechanisms and are an important approach to developing improved diagnostics and therapeutics. Current murine models of neonatal bacterial infection employ intraperitoneal or subcutaneous routes at several days of age, and may, therefore, not accurately reflect distinct features of innate immune responses to bacteremia. In this study we d